HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-(4-chlorobenzoyl)-3-methylisothiazol-5-ylcarbamate → (5-Amino-3-methylisothiazol-4-yl)(4-chlorophenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-(4-chlorobenzoyl)-3-methylisothiazol-5-ylcarbamate | HCID 67814309 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | (5-Amino-3-methylisothiazol-4-yl)(4-chlorophenyl)methanone | HCID 67814140 | 74.8% |
Reaction Steps
To tert-butyl 4-(4-chlorobenzoyl)-3-methylisothiazol-5-ylcarbamate (2.80 g, 7.94 mmol) was added an excess of TFA (20 mL). After a period of 15 min at reflux, the reaction mixture was evaporated under reduced pressure to give (5-amino-3-methylisothiazol-4-yl)(4-chlorophenyl)methanone as a white solid (1.50 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249161B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-17cae3036e9141de9da3f527d97d94ad |
| Source note | uspto-grants-2016_02 |