反应详情

To tert-butyl 4-(4-chlorobenzoyl)-3-methylisothiazol-5-ylcarbamate (2.80 g, 7.94 mmol) was added an excess of TFA (20 mL). After a period of 15 min at reflux, the reaction mixture was evaporated under reduced pressure to give (5-amino-3-methylisothiazol-4-yl)(4-chlorophenyl)methanone as a white solid (1.50 g).

1. temperatureAfter a period of 15 min at reflux
2. customthe reaction mixture was evaporated under reduced pressure