反应详情

A round bottomed flask was charged with racemic (1S,2R)-ethyl 1-((diphenylmethylene)amino)-2-methylcyclopropanecarboxylate and a stir bar. Et2O (50 mL, 0.5 M) was added, and the mixture was cooled to 0° C. for the addition of 1 N HCl (9 mL, 1.2 equiv). The solution was warmed to room temperature and stirred overnight. The mixture was separated, and the organic layer was washed twice with water before being dried with Na2SO4 and concentrated. Lyophilization yielded racemic (1S,2R)-ethyl 1-amino-2-methylcyclopropanecarboxylate hydrochloride as a colorless oil that solidified upon sitting (yield not determined). LRMS (M+H)+: 144 m/z.

1. customThe mixture was separated
2. washthe organic layer was washed twice with water
3. dry with materialbefore being dried with Na2SO4
4. concentrationconcentrated