Ethyl 1-aminocyclobutane-1-carboxylate hydrochloride → 5'-(4-chlorophenyl)-6',7'-dimethylspiro[cyclobutane-1,3'-thieno[2,3-e][1,4]diazepin]-2'(1'H)-one

HRID 1772364Notes

Reaction equation

HRID 1772364 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:14]3[C:15]([CH3:19])=[C:16]([CH3:18])[S:17][C:13]=3[N:12]3C(C)=NN=C3C(C)(C)N=2)=[CH:4][CH:3]=1.Cl.[NH2:27][C:28]1([C:32]([O:34]CC)=O)[CH2:31][CH2:30][CH2:29]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:14]3[C:15]([CH3:19])=[C:16]([CH3:18])[S:17][C:13]=3[NH:12][C:32](=[O:34])[C:28]3([CH2:29][CH2:30][CH2:31]3)[N:27]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 16217503Ethyl 1-aminocyclobutane-1-carboxylate hydrochlorideHCID 545887644-(4-chlorophenyl)-2,3,6,6,9-pentamethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

Product 1

HCID 1363380695'-(4-chlorophenyl)-6',7'-dimethylspiro[cyclobutane-1,3'-thieno[2,3-e][1,4]diazepin]-2'(1'H)-one

Procedure

A procedure analogous to that set forth in the synthesis of Compound 214 was followed, with the exception that ethyl 1-aminocyclobutanecarboxylate hydrochloride was used as starting material. LRMS (M+H)+: 345 m/z.

Sources & evidence

ORD record
ord-5ef46302fbfb4ec2a88a64e2925b00a7
Source dataset
uspto-grants-2016_02
Patent number
US09249161B2

Reaction notes

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