HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-aminocyclobutane-1-carboxylate hydrochloride → 5'-(4-chlorophenyl)-6',7'-dimethylspiro[cyclobutane-1,3'-thieno[2,3-e][1,4]diazepin]-2'(1'H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-aminocyclobutane-1-carboxylate hydrochloride | HCID 16217503 | — |
| Reactant | 4-(4-chlorophenyl)-2,3,6,6,9-pentamethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine | HCID 54588764 | — |
| Product | 5'-(4-chlorophenyl)-6',7'-dimethylspiro[cyclobutane-1,3'-thieno[2,3-e][1,4]diazepin]-2'(1'H)-one | HCID 136338069 | — |
Reaction Steps
A procedure analogous to that set forth in the synthesis of Compound 214 was followed, with the exception that ethyl 1-aminocyclobutanecarboxylate hydrochloride was used as starting material. LRMS (M+H)+: 345 m/z.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249161B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5ef46302fbfb4ec2a88a64e2925b00a7 |
| Source note | uspto-grants-2016_02 |