3-Aminooxetane-3-carboxylic acid → 4'-(4-Chlorophenyl)-2',3',9'-trimethylspiro[oxetane-3,6'-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

HRID 1772368Notes

Reaction equation

HRID 1772368 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:14]3[C:15]([CH3:19])=[C:16]([CH3:18])[S:17][C:13]=3[N:12]3[C:20]([CH3:23])=[N:21][N:22]=[C:11]3[C:10]3([CH2:26]N[CH2:24]3)[N:9]=2)=[CH:4][CH:3]=1.NC1(C(O)=O)C[O:30]C1.NC1(C(O)=O)CN(C(OC(C)(C)C)=O)C1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:14]3[C:15]([CH3:19])=[C:16]([CH3:18])[S:17][C:13]=3[N:12]3[C:20]([CH3:23])=[N:21][N:22]=[C:11]3[C:10]3([CH2:26][O:30][CH2:24]3)[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 150242563-Aminooxetane-3-carboxylic acidHCID 534147103-Amino-1-[(tert-butoxy)carbonyl]azetidine-3-carboxylic acidHCID 574054324'-(4-Chlorophenyl)-2',3',9'-trimethylspiro[azetidine-3,6'-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

Product 1

HCID 574054334'-(4-Chlorophenyl)-2',3',9'-trimethylspiro[oxetane-3,6'-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

Procedure

A procedure analogous to the scheme set forth for the synthesis of Compound 224 was followed, with the exception that 3-aminooxetane-3-carboxylic acid was used as starting material instead of 3-amino-1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid.

Sources & evidence

ORD record
ord-64fa008fe1d4450abbbe7556a3ea583d
Source dataset
uspto-grants-2016_02
Patent number
US09249161B2

Reaction notes

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