反应详情

温度

80 °C

To a solution of 4-bromobenzaldehyde (4.30 g, 23.2 mmol) in EtOH (40 mL) was added 1-amino-1-methylurea (2.50 g, 28.1 mmol), AcOH (2.5 mL) and H2O (4.5 mL). The resulting solution was stirred at 80° C. overnight. After cooling to rt, Et2O (200 mL) was added. The resulting solids were collected by filtration to obtain compound 10a as a white solid (5.80 g, 97% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C9H10BrN3O: 256.0 (M+H). Found 256.1.

1. temperatureAfter cooling to rt
2. filtrationThe resulting solids were collected by filtration