2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 123860259, compound

HRID 1772612Notes

Reaction equation

HRID 1772612 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[N:11][C:10](=[O:13])[NH:9]2)=[CH:4][CH:3]=1.[CH3:14][Si:15]([CH2:18][CH2:19][O:20][CH2:21]Cl)([CH3:17])[CH3:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[N:11][C:10](=[O:13])[N:9]2[CH2:21][O:20][CH2:19][CH2:18][Si:15]([CH3:17])([CH3:16])[CH3:14])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 234341921-(4-Bromophenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one

Product 1

HCID 123860259HCID 123860259, compoundYield 58%

Procedure

Compound 11b (30.0 g, 125 mmol) was treated with SEMCl using the reaction conditions described in Example 10, Step C to obtain compound 11c as a white solid (30.0 g, 58% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C14H20BrN3O2S: 370.1 (M+H). Found 370.2.

Workup

  1. customthe reaction conditions

Sources & evidence

ORD record
ord-e79b0d5e55314533a78afe896f6d062d
Source dataset
uspto-grants-2016_02
Patent number
US09249163B2

Reaction notes

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