Hydrazine hydrate (1:1) → 5-Bromo-8-morpholinoimidazo[1,2-a]pyrazine-2-carbohydrazide

Participants

Reaction Steps

A mixture of compound 21a (1.6 g, 4.5 mmol) and hydrazine monohydrate (2.6 mL, 27 mmol) in EtOH (20 mL) was heated at reflux overnight. An off-white solid formed, the collected by filtration and dried under reduced pressure to give 5-bromo-8-morpholinoimidazo[1,2-a]pyrazine-2-carbohydrazide which was directly used in next step without further purification.

Provenance & Evidence