反应详情

A mixture of compound 21a (1.6 g, 4.5 mmol) and hydrazine monohydrate (2.6 mL, 27 mmol) in EtOH (20 mL) was heated at reflux overnight. An off-white solid formed, the collected by filtration and dried under reduced pressure to give 5-bromo-8-morpholinoimidazo[1,2-a]pyrazine-2-carbohydrazide which was directly used in next step without further purification.

1. temperaturewas heated
2. temperatureat reflux overnight
3. customAn off-white solid formed
4. filtrationthe collected by filtration
5. customdried under reduced pressure