2-Chloropyrimidine → tert-Butyl 4-(5-(8-morpholino-2-((pyrimidin-2-yloxy)methyl)imidazo[1,2-a]pyrazin-5-yl)pyridin-2-yl)piperazine-1-carboxylate

HRID 1772641Notes

Reaction equation

HRID 1772641 reaction equation
[OH:1][CH2:2][C:3]1[N:4]=[C:5]2[C:10]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)=[N:9][CH:8]=[C:7]([C:17]3[CH:18]=[CH:19][C:20]([N:23]4[CH2:28][CH2:27][N:26]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:25][CH2:24]4)=[N:21][CH:22]=3)[N:6]2[CH:36]=1.Cl[C:38]1[N:43]=[CH:42][CH:41]=[CH:40][N:39]=1>>[O:14]1[CH2:13][CH2:12][N:11]([C:10]2[C:5]3[N:6]([CH:36]=[C:3]([CH2:2][O:1][C:38]4[N:43]=[CH:42][CH:41]=[CH:40][N:39]=4)[N:4]=3)[C:7]([C:17]3[CH:18]=[CH:19][C:20]([N:23]4[CH2:24][CH2:25][N:26]([C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])[CH2:27][CH2:28]4)=[N:21][CH:22]=3)=[CH:8][N:9]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 744042-ChloropyrimidineHCID 117733761tert-Butyl 4-(5-(2-(hydroxymethyl)-8-morpholinoimidazo[1,2-a]pyrazin-5-yl)pyridin-2-yl)piperazine-1-carboxylate

Product 1

HCID 131734674tert-Butyl 4-(5-(8-morpholino-2-((pyrimidin-2-yloxy)methyl)imidazo[1,2-a]pyrazin-5-yl)pyridin-2-yl)piperazine-1-carboxylate

Procedure

Following the procedures described in Example 22, Step A, the title compound was prepared from compound 23a and 2-chloropyrimidine. Mass Spectrum (LCMS, ESI pos.) Calcd. for C29H35N9O4: 574.3 (M+H). Found 574.3.

Sources & evidence

ORD record
ord-fd0761f1a6a14035b15cb8488ddc635e
Source dataset
uspto-grants-2016_02
Patent number
US09249163B2

Reaction notes

Loading…