HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyrimidine → tert-Butyl 4-(5-(8-morpholino-2-((pyrimidin-2-yloxy)methyl)imidazo[1,2-a]pyrazin-5-yl)pyridin-2-yl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Reactant | tert-Butyl 4-(5-(2-(hydroxymethyl)-8-morpholinoimidazo[1,2-a]pyrazin-5-yl)pyridin-2-yl)piperazine-1-carboxylate | HCID 117733761 | — |
| Product | tert-Butyl 4-(5-(8-morpholino-2-((pyrimidin-2-yloxy)methyl)imidazo[1,2-a]pyrazin-5-yl)pyridin-2-yl)piperazine-1-carboxylate | HCID 131734674 | — |
Reaction Steps
Following the procedures described in Example 22, Step A, the title compound was prepared from compound 23a and 2-chloropyrimidine. Mass Spectrum (LCMS, ESI pos.) Calcd. for C29H35N9O4: 574.3 (M+H). Found 574.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249163B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-fd0761f1a6a14035b15cb8488ddc635e |
| Source note | uspto-grants-2016_02 |