HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetic Acid → Hydrogen Bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetic Acid | HCID 6227 | — |
| Reactant | 2-Amino-3-morpholin-4-ylpyrazine | HCID 45480314 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Hydrogen Bromide | HCID 260 | — |
| Product | 8-Morpholinoimidazo[1,2-a]pyrazin-2-ol | HCID 69942422 | — |
Reaction Steps
Compound 1b (6.0 g, 33 mmol) and bromoacetic acid (5.3 g, 38 mmol) in isopropanol (100 mL) were heated at 90° C. overnight. The reaction mixture was allowed to cool to rt and the solids formed were collected by suction filtration to obtain 8-morpholinoimidazo[1,2-a]pyrazin-2-ol as its HBr salt. This compound was used in next step without further purifications.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249163B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-49b8db13e0b94e579d79e0b2062b8fcf |
| Source note | uspto-grants-2016_02 |