反应详情

Compound 1b (6.0 g, 33 mmol) and bromoacetic acid (5.3 g, 38 mmol) in isopropanol (100 mL) were heated at 90° C. overnight. The reaction mixture was allowed to cool to rt and the solids formed were collected by suction filtration to obtain 8-morpholinoimidazo[1,2-a]pyrazin-2-ol as its HBr salt. This compound was used in next step without further purifications.

1. customthe solids formed
2. filtrationwere collected by suction filtration