Bromoacetic Acid → Hydrogen Bromide

HRID 1772642Notes

Reaction equation

HRID 1772642 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]([NH2:13])=[N:9][CH:10]=[CH:11][N:12]=2)[CH2:3][CH2:2]1.[Br:14][CH2:15][C:16](O)=[O:17]>C(O)(C)C>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:9]([CH:15]=[C:16]([OH:17])[N:13]=3)[CH:10]=[CH:11][N:12]=2)[CH2:3][CH2:2]1.[BrH:14]

Participants

5

Reactant 2

HCID 6227Bromoacetic AcidHCID 454803142-Amino-3-morpholin-4-ylpyrazine

Product 2

HCID 260Hydrogen BromideHCID 699424228-Morpholinoimidazo[1,2-a]pyrazin-2-ol

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Compound 1b (6.0 g, 33 mmol) and bromoacetic acid (5.3 g, 38 mmol) in isopropanol (100 mL) were heated at 90° C. overnight. The reaction mixture was allowed to cool to rt and the solids formed were collected by suction filtration to obtain 8-morpholinoimidazo[1,2-a]pyrazin-2-ol as its HBr salt. This compound was used in next step without further purifications.

Workup

  1. customthe solids formed
  2. filtrationwere collected by suction filtration

Sources & evidence

ORD record
ord-49b8db13e0b94e579d79e0b2062b8fcf
Source dataset
uspto-grants-2016_02
Patent number
US09249163B2

Reaction notes

Loading…