HCID 117732281, compound → Benzyl 4-(5-(2-(1-(tert-butoxycarbonyl)azetidin-3-yl)-8-morpholinoimidazo[1,2-a]pyrazin-5-yl)pyridin-2-yl)piperazine-1-carboxylate
Reaction equation
Br[C:2]1[N:7]2[CH:8]=[C:9]([CH:11]3[CH2:14][N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:12]3)[N:10]=[C:6]2[C:5]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:4][CH:3]=1.CC1(C)C(C)(C)OB([C:36]2[CH:37]=[CH:38][C:39]([N:42]3[CH2:47][CH2:46][N:45]([C:48]([O:50][CH2:51][C:52]4[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=4)=[O:49])[CH2:44][CH2:43]3)=[N:40][CH:41]=2)O1>>[C:18]([O:17][C:15]([N:13]1[CH2:14][CH:11]([C:9]2[N:10]=[C:6]3[C:5]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[N:4][CH:3]=[C:2]([C:36]4[CH:37]=[CH:38][C:39]([N:42]5[CH2:47][CH2:46][N:45]([C:48]([O:50][CH2:51][C:52]6[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=6)=[O:49])[CH2:44][CH2:43]5)=[N:40][CH:41]=4)[N:7]3[CH:8]=2)[CH2:12]1)=[O:16])([CH3:21])([CH3:20])[CH3:19]Participants
3
Reactant 2
Product 1
Procedure
Compound 29b was subjected to Suzuki coupling reaction conditions with benzyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine-1-carboxylate using the methods described in Example 1, Step G to obtain compound 29c. Mass Spectrum (LCMS, ESI pos.) Calcd. for C35H42N8O5: 655.3 (M+H). Found 655.3.
Sources & evidence
- ORD record
- ord-dad0d4b1db2149c4935dc5daba09a8d1
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09249163B2
Reaction notes
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