Hydroxylamine → HCID 136942070, compound

HRID 1772699Notes

Reaction equation

HRID 1772699 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:9]([CH:15]=[C:16]([CH2:18][O:19][C:20]4[CH:29]=[CH:28][C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[N:21]=4)[N:17]=3)[C:10]([C:13]#[N:14])=[CH:11][N:12]=2)[CH2:3][CH2:2]1.[NH2:30][OH:31]>CCO>[OH:31]/[N:30]=[C:13](/[C:10]1[N:9]2[CH:15]=[C:16]([CH2:18][O:19][C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[N:21]=3)[N:17]=[C:8]2[C:7]([N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:12][CH:11]=1)\[NH2:14]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 86345858HCID 86345858, compound

Product 1

HCID 136942070HCID 136942070, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of compound 55a (100 mg, 0.26 mmol) and hydroxylamine (50% wt, 0.086 mL, 1.4 mmol) in EtOH (2 mL) was heated to 90° C. for 5 h. The precipitate obtained was collected by filtration, washed with EtOH, and dried to give compound 55b. Mass Spectrum (LCMS, ESI pos.) Calcd. for C21H21N7O3: 420.2 [M+H]. found 420.2

Workup

  1. customThe precipitate obtained
  2. filtrationwas collected by filtration
  3. washwashed with EtOH
  4. customdried

Sources & evidence

ORD record
ord-66ac6eaa9f8a455b8558d5f9dd60ea77
Source dataset
uspto-grants-2016_02
Patent number
US09249163B2

Reaction notes

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