Pyridine → 2-Amino-5-(4-pyridyl)-4-[(4-piperonyl-1-piperazinyl)carbonyl]thiazole

HRID 177276Notes

Reaction equation

HRID 177276 reaction equation
[CH2:1]([c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[O:7][CH2:6][O:5]2)[N:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1.[NH2:21][c:22]1[s:23][c:24](-[c:30]2[cH:31][cH:32][n:33][cH:34][cH:35]2)[c:25]([C:27](=[O:28])[OH:29])[n:26]1.[P:17]([Cl:18])([Cl:19])[Cl:20].[cH:36]1[cH:37][cH:38][n:39][cH:40][cH:41]1>>[CH2:1]([c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[O:7][CH2:6][O:5]2)[N:11]1[CH2:12][CH2:13][N:14]([C:27]([c:25]2[c:24](-[c:30]3[cH:31][cH:32][n:33][cH:34][cH:35]3)[s:23][c:22]([NH2:21])[n:26]2)=[O:28])[CH2:15][CH2:16]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 24387Phosphorus trichlorideHCID 944261-PiperonylpiperazineHCID 201449862-Amino-5-(pyridin-4-yl)-1,3-thiazole-4-carboxylic acid

Product 1

HCID 201450812-Amino-5-(4-pyridyl)-4-[(4-piperonyl-1-piperazinyl)carbonyl]thiazole

Sources & evidence

ORD record
ord-8388637794fc4bd3b9307834c49519c5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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