Pyridine → N-(5,6-Dimethoxypyridin-3-yl)-2-nitrobenzenesulfonamide

HRID 1772862Notes

Reaction equation

HRID 1772862 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10](Cl)(=[O:12])=[O:11])([O-:3])=[O:2].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([NH2:24])[CH:19]=[N:20][C:21]=1[O:22][CH3:23].N1C=CC=CC=1>>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([NH:24][S:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N+:1]([O-:3])=[O:2])(=[O:12])=[O:11])[CH:19]=[N:20][C:21]=1[O:22][CH3:23]

Participants

4

Reactant 3

HCID 1049PyridineHCID 155402-Nitrobenzenesulfonyl chlorideHCID 127582145,6-Dimethoxypyridin-3-amine

Product 1

HCID 118045902N-(5,6-Dimethoxypyridin-3-yl)-2-nitrobenzenesulfonamideYield 38.3%

Procedure

The title compound (1.56 g, 4.60 mmol) was prepared from 2-nitrobenzenesulfonyl chloride (2.66 g, 12.0 mmol), 5,6-dimethoxy-3-pyridinamine (2.04 g, 13.2 mmol) and pyridine (2.9 mL, 36.0 mmol) using the methods of (IntA1), step 1.

Sources & evidence

ORD record
ord-d157be4b095141daaeb6de0947898412
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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