反应详情

温度

90 °C

A mixture of 6-bromo-3-methoxy-2-nitropyridine (14.4 g, 61.8 mmol), AcOH (200 mL) and Fe powder (14.0 g, 0.25 mol) was stirred at 90° C. for 1.5 h. After cooling to rt and dilution with EtOAc the mixture was filtered through celite and the filtrate concentrated in vacuo. Purification by flash chromatography eluting with DCM yielded the title compound (10.2 g, 50.2 mmol) as a white solid.

1. temperatureAfter cooling to rt
2. filtrationdilution with EtOAc the mixture was filtered through celite
3. concentrationthe filtrate concentrated in vacuo
4. customPurification by flash chromatography
5. washeluting with DCM