Pyridine → 2-Chloro-N-(5,6-dimethoxypyridin-2-yl)pyridine-3-sulfonamide

HRID 1772903노트

반응식

HRID 1772903 반응식
[Cl:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([NH2:22])=[N:18][C:19]=1[O:20][CH3:21].N1C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[C:7]([S:8]([NH:22][C:17]2[CH:16]=[CH:15][C:14]([O:13][CH3:12])=[C:19]([O:20][CH3:21])[N:18]=2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 102199682-Chloropyridine-3-sulfonyl chlorideHCID 467391485,6-Dimethoxypyridin-2-amine

생성물 1

HCID 900227962-Chloro-N-(5,6-dimethoxypyridin-2-yl)pyridine-3-sulfonamide수율 66.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound (549 mg, 1.66 mmol) was prepared from 2-chloropyridine-3-sulfonyl chloride (530 mg, 2.5 mmol), 5,6-dimethoxypyridin-2-amine (424 mg, 2.8 mmol) and pyridine (0.6 mL, 7.5 mmol) in DCM (10 mL) using the methods of (IntC1).

출처 및 근거

ORD 기록
ord-b14f3c065fb44b75b86ff0a99ce25084
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249160B2

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