6-Aminobenzothiazole → N-(1,3-Benzothiazol-6-yl)-2-chloropyridine-3-sulfonamide

HRID 1772909Notes

Reaction equation

HRID 1772909 reaction equation
[Cl:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[S:12]1[C:16]2[CH:17]=[C:18]([NH2:21])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1>N1C=CC=CC=1>[S:12]1[C:16]2[CH:17]=[C:18]([NH:21][S:8]([C:7]3[C:2]([Cl:1])=[N:3][CH:4]=[CH:5][CH:6]=3)(=[O:10])=[O:9])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1

Participants

4

Reactant 2

HCID 682886-AminobenzothiazoleHCID 102199682-Chloropyridine-3-sulfonyl chloride

Product 1

HCID 90030239N-(1,3-Benzothiazol-6-yl)-2-chloropyridine-3-sulfonamideYield 50.8%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound (1.1 g, 3.38 mmol) was prepared from 2-chloropyridine-3-sulfonyl chloride (1.56 g, 7.36 mmol), 1,3-benzothiazol-6-amine (1.0 g, 6.66 mmol) and pyridine (10 mL) at rt using the methods of (IntC1).

Sources & evidence

ORD record
ord-f04a18d6559a4884b5636e6589fe8780
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

Loading…