6-Amino-2,3-dimethylpyridine → 2-chloro-N-(5,6-dimethylpyridin-2-yl)pyridine-3-sulfonamide

HRID 1772930Notes

Reaction equation

HRID 1772930 reaction equation
[Cl:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][C:13]1[CH:14]=[CH:15][C:16]([NH2:20])=[N:17][C:18]=1[CH3:19]>N1C=CC=CC=1>[Cl:1][C:2]1[C:7]([S:8]([NH:20][C:16]2[CH:15]=[CH:14][C:13]([CH3:12])=[C:18]([CH3:19])[N:17]=2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 2624846-Amino-2,3-dimethylpyridineHCID 102199682-Chloropyridine-3-sulfonyl chloride

Product 1

HCID 900306792-chloro-N-(5,6-dimethylpyridin-2-yl)pyridine-3-sulfonamideYield 85.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound (5.0 g, 16.8 mmol) was prepared from 2-chloropyridine-3-sulfonyl chloride (5.0 g, 23.7 mmol) and 5,6-dimethylpyridin-2-amine (2.4 g, 19.6 mmol) in pyridine (25 mL) at rt using the methods of (IntC1), step 1.

Sources & evidence

ORD record
ord-fbb73121577d4a2b909a4d4609d65a3d
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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