Triphosgene → HCID 90022462, compound

HRID 1772931Notes

Reaction equation

HRID 1772931 reaction equation
[NH2:1][C:2]1[C:7]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[N:13]=2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[C:21](Cl)([O:23]C(=O)OC(Cl)(Cl)Cl)Cl>O1CCOCC1>[CH3:18][C:15]1[CH:16]=[CH:17][C:12]([N:11]2[C:21](=[O:23])[NH:1][C:2]3[N:3]=[CH:4][CH:5]=[CH:6][C:7]=3[S:8]2(=[O:10])=[O:9])=[N:13][C:14]=1[CH3:19]

Participants

4

Reactant 2

HCID 94429TriphosgeneHCID 90030655HCID 90030655, compound

Product 1

HCID 90022462HCID 90022462, compoundYield 60.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound (0.4 g, 1.31 mmol) was prepared from 2-amino-N-(5,6-dimethylpyridin-2-yl)pyridine-3-sulfonamide (0.6 g, 2.16 mmol) and triphosgene (0.7 g, 2.36 mmol) in 1,4-dioxane (15 mL) at 80° C. using the methods of (IntA1), step 3.

Sources & evidence

ORD record
ord-39be64bccda843af9efb617da4762f76
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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