Potassium Carbonate → 4-(2-Chloro-6-fluorobenzyl)-2-(4-methoxy-3,5-dimethylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772939Notes

Reaction equation

HRID 1772939 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4]Br.C([O-])([O-])=O.[K+].[K+].[CH3:17][O:18][C:19]1[C:24]([CH3:25])=[CH:23][C:22]([N:26]2[C:31](=[O:32])[N:30](CC3C(F)=CC(F)=CC=3F)[C:29]3[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=3[S:27]2(=[O:48])=[O:47])=[CH:21][C:20]=1[CH3:49]>O1CCOCC1>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][N:30]1[C:29]2[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=2[S:27](=[O:48])(=[O:47])[N:26]([C:22]2[CH:23]=[C:24]([CH3:25])[C:19]([O:18][CH3:17])=[C:20]([CH3:49])[CH:21]=2)[C:31]1=[O:32]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27736252-Chloro-6-fluorobenzyl bromideHCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Product 1

HCID 727212754-(2-Chloro-6-fluorobenzyl)-2-(4-methoxy-3,5-dimethylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound (0.20 g, 0.42 mmol) was prepared from (IntA6) (0.35 g, 1.00 mmol), 2-chloro-6-fluorobenzyl bromide (0.34 g, 1.5 mmol) and K2CO3 (0.20 g, 1.5 mmol) in 1,4-Dioxane (10 mL) using the methods of (115).

Sources & evidence

ORD record
ord-f646ea65def64c38bf19f378b3be8df9
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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