Potassium Carbonate → 4-(2,6-Dichlorobenzyl)-2-(3,4-di methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772941ノート

反応式

HRID 1772941 の反応式
[C:1]([O-])([O-])=[O:2].[K+].[K+].[Cl:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:9]=1[CH2:10]Cl.[CH3:17][O:18][C:19]1[C:24](C)=[CH:23][C:22]([N:26]2[C:31](=[O:32])[N:30](CC3C(F)=CC(F)=CC=3F)[C:29]3[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=3[S:27]2(=[O:48])=[O:47])=[CH:21][C:20]=1C>CN(C=O)C>[Cl:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:9]=1[CH2:10][N:30]1[C:29]2[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=2[S:27](=[O:47])(=[O:48])[N:26]([C:22]2[CH:21]=[CH:20][C:19]([O:18][CH3:17])=[C:24]([O:2][CH3:1])[CH:23]=2)[C:31]1=[O:32]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 748322,6-Dichlorobenzyl chlorideHCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

生成物 1

HCID 727211774-(2,6-Dichlorobenzyl)-2-(3,4-di methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The title compound (52 mg, 0.11 mmol) was prepared from (IntA1) (67 mg, 0.20 mmol), K2CO3 (83 mg, 0.60 mmol) and 2,6-dichlorobenzyl chloride (47 mg, 0.24 mmol) in DMF (2 mL) using the methods of (115).

出典と根拠

ORDレコード
ord-147a6dc193de46198f9533d273b59058
出典データセット
uspto-grants-2016_02
特許番号
US09249160B2

反応ノート

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