Dimethylformamide → 4-(2-Chloro-6-fluorobenzyl)-2-(3,5-di methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

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Reaktionsgleichung

[C:1]([O-:4])([O-])=O.[K+].[K+].[Cl:7]C1C=CC=C(F)C=1CBr.CO[C:19]1[C:24](C)=[CH:23][C:22]([N:26]2[C:31](=[O:32])[N:30]([CH2:33][C:34]3[C:39](F)=[CH:38][C:37](F)=[CH:36][C:35]=3[F:42])[C:29]3[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=3[S:27]2(=[O:48])=[O:47])=[CH:21][C:20]=1C.CN([CH:53]=[O:54])C>>[Cl:7][C:39]1[CH:38]=[CH:37][CH:36]=[C:35]([F:42])[C:34]=1[CH2:33][N:30]1[C:29]2[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=2[S:27](=[O:47])(=[O:48])[N:26]([C:22]2[CH:23]=[C:24]([O:54][CH3:53])[CH:19]=[C:20]([O:4][CH3:1])[CH:21]=2)[C:31]1=[O:32]

Komponenten

Edukt 4

HCID 6228Dimethylformamide

HCID 11430Potassium Carbonate

HCID 27736252-Chloro-6-fluorobenzyl bromide

HCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Produkt 1

HCID 727210844-(2-Chloro-6-fluorobenzyl)-2-(3,5-di methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Versuchsvorschrift

The title compound (61 mg, 0.13 mmol) was prepared from (IntA11) (67 mg, 0.20 mmol), K2CO3 (83 mg, 0.60 mmol) and 2-chloro-6-fluorobenzyl bromide (54 mg, 0.24 mmol) in DMF (2 mL) using the methods of (115).

Quellen und Nachweise

ORD-Eintrag: ord-773932398cb949aaa32f2295f0d8a9a1
Quelldatensatz: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09249160B2

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