Dimethylformamide → 4-(2-Chloro-6-fluorobenzyl)-2-(3,5-di methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

関与物質

役割	名称	HCID	仕込み量
反応物	Dimethylformamide	HCID 6228	—
反応物	Potassium Carbonate	HCID 11430	—
反応物	2-Chloro-6-fluorobenzyl bromide	HCID 2773625	—
反応物	2-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 72722085	—
生成物	4-(2-Chloro-6-fluorobenzyl)-2-(3,5-di methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 72721084	—

反応手順

The title compound (61 mg, 0.13 mmol) was prepared from (IntA11) (67 mg, 0.20 mmol), K2CO3 (83 mg, 0.60 mmol) and 2-chloro-6-fluorobenzyl bromide (54 mg, 0.24 mmol) in DMF (2 mL) using the methods of (115).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09249160B2
出典データセット	uspto-grants-2016_02
ORD ID	ord-773932398cb949aaa32f2295f0d8a9a1
出典メモ	uspto-grants-2016_02