Potassium Carbonate → 4-[(3,5-Dimethyl pyridin-2-yl)methyl]-2-(3,4-di methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772945ノート

反応式

HRID 1772945 の反応式
[C:1]([O-])([O-])=[O:2].[K+].[K+].Cl[CH2:8][C:9]1[C:14]([CH3:15])=[CH:13][C:12]([CH3:16])=[CH:11][N:10]=1.[CH3:17][O:18][C:19]1[C:24](C)=[CH:23][C:22]([N:26]2[C:31](=[O:32])[N:30](CC3C(F)=CC(F)=CC=3F)[C:29]3[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=3[S:27]2(=[O:48])=[O:47])=[CH:21][C:20]=1C>CN(C=O)C>[CH3:15][C:14]1[C:9]([CH2:8][N:30]2[C:29]3[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=3[S:27](=[O:47])(=[O:48])[N:26]([C:22]3[CH:21]=[CH:20][C:19]([O:18][CH3:17])=[C:24]([O:2][CH3:1])[CH:23]=3)[C:31]2=[O:32])=[N:10][CH:11]=[C:12]([CH3:16])[CH:13]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 155943992-(Chloromethyl)-3,5-dimethylpyridineHCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

生成物 1

HCID 727209844-[(3,5-Dimethyl pyridin-2-yl)methyl]-2-(3,4-di methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The title compound (89 mg, 0.20 mmol) was prepared from (IntA1) (167 mg, 0.50 mmol), K2CO3 (207 mg, 1.5 mmol) and 2-(chloromethyl)-3,5-dimethylpyridine (93 mg, 0.6 mmol) in DMF (5 mL) using the methods of (115).

出典と根拠

ORDレコード
ord-556f4ff14cc44d49a111b76f4da4c27e
出典データセット
uspto-grants-2016_02
特許番号
US09249160B2

反応ノート

読み込み中…