Dimethylformamide → 4-(2,6-Difluoro-4-methoxybenzyl)-2-(6-methoxypyridin-2-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772946노트

반응식

[C:1]([O-:4])([O-])=O.[K+].[K+].FC1C=[C:14]([O:16][CH3:17])[CH:13]=[C:12](F)C=1CBr.COC1C(C)=C[C:24]([N:28]2[C:33](=[O:34])[N:32]([CH2:35][C:36]3[C:41]([F:42])=[CH:40][C:39](F)=[CH:38][C:37]=3[F:44])[C:31]3[CH:45]=[CH:46][CH:47]=[CH:48][C:30]=3[S:29]2(=[O:50])=[O:49])=[CH:23]C=1C.C[N:53](C=O)C>>[F:44][C:37]1[CH:38]=[C:39]([O:4][CH3:1])[CH:40]=[C:41]([F:42])[C:36]=1[CH2:35][N:32]1[C:31]2[CH:45]=[CH:46][CH:47]=[CH:48][C:30]=2[S:29](=[O:49])(=[O:50])[N:28]([C:24]2[CH:23]=[CH:12][CH:13]=[C:14]([O:16][CH3:17])[N:53]=2)[C:33]1=[O:34]

참가 물질

반응물 4

HCID 6228Dimethylformamide

HCID 11430Potassium Carbonate

HCID 33542722,6-Difluoro-4-methoxybenzyl bromide

HCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

생성물 1

HCID 727210804-(2,6-Difluoro-4-methoxybenzyl)-2-(6-methoxypyridin-2-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

실험 절차

The title compound (99 mg, 0.21 mmol) was prepared from (IntA5) (92 mg, 0.30 mmol), K2CO3 (124 mg, 0.9 mmol) and 2,6-difluoro-4-methoxybenzyl bromide (85 mg, 0.36 mmol) in DMF (3 mL) using the methods of (115).

출처 및 근거

ORD 기록: ord-23760721c00d4ee4b9ee6364e5646325
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09249160B2

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