Dimethylformamide → 4-(2,6-Difluoro-4-methoxybenzyl)-2-(6-methoxypyridin-2-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2,6-Difluoro-4-methoxybenzyl bromide	HCID 3354272	—
Reactant	2-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 72722085	—
Product	4-(2,6-Difluoro-4-methoxybenzyl)-2-(6-methoxypyridin-2-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 72721080	—

Reaction Steps

The title compound (99 mg, 0.21 mmol) was prepared from (IntA5) (92 mg, 0.30 mmol), K2CO3 (124 mg, 0.9 mmol) and 2,6-difluoro-4-methoxybenzyl bromide (85 mg, 0.36 mmol) in DMF (3 mL) using the methods of (115).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09249160B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-23760721c00d4ee4b9ee6364e5646325
Source note	uspto-grants-2016_02