Potassium Carbonate → HCID 90055058, compound

HRID 1772989Notes

Reaction equation

HRID 1772989 reaction equation
Br[CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.C([O-])([O-])=O.[K+].[K+].[Cl:15][C:16]1[CH:42]=[CH:41][CH:40]=[C:39]([F:43])[C:17]=1[CH2:18][N:19]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[S:22](=[O:30])(=[O:29])[N:21](CC2C=CC=CN=2)[C:20]1=[O:38]>>[Cl:15][C:16]1[CH:42]=[CH:41][CH:40]=[C:39]([F:43])[C:17]=1[CH2:18][N:19]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[S:22](=[O:30])(=[O:29])[N:21]([CH2:2][CH:3]2[CH2:8][CH2:7][O:6][CH2:5][CH2:4]2)[C:20]1=[O:38]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 27732864-(Bromomethyl)oxaneHCID 90054655HCID 90054655, compound

Product 1

HCID 90055058HCID 90055058, compound

Procedure

The title compound (150 mg, 0.34 mmol) was prepared from (IntE1) (0.3 g, 0.88 mmol), 4-(bromomethyl)tetrahydro-2H-pyran (0.20 g, 1.05 mmol) and K2CO3 (0.36 g, 2.60 mmol) using the methods of (128).

Sources & evidence

ORD record
ord-63f853ea35234d39a69d5e83697f27b6
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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