3-Bromo-4-(trifluoromethoxy)aniline → 6-(((3-Bromo-4-(trifluoromethoxy)phenyl)amino)methyl)-3-methylbenzofuran-2-carbonitrile

HRID 1773233Notes

Reaction equation

HRID 1773233 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][C:10]([F:13])([F:12])[F:11])[NH2:5].[CH:14]([C:16]1[CH:27]=[CH:26][C:19]2[C:20]([CH3:25])=[C:21]([C:23]#[N:24])[O:22][C:18]=2[CH:17]=1)=O>>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][CH2:14][C:16]2[CH:27]=[CH:26][C:19]3[C:20]([CH3:25])=[C:21]([C:23]#[N:24])[O:22][C:18]=3[CH:17]=2)[CH:6]=[CH:7][C:8]=1[O:9][C:10]([F:11])([F:12])[F:13]

Participants

3

Reactant 2

HCID 27364183-Bromo-4-(trifluoromethoxy)anilineHCID 1184526596-Formyl-3-methylbenzofuran-2-carbonitrile

Product 1

HCID 1184526466-(((3-Bromo-4-(trifluoromethoxy)phenyl)amino)methyl)-3-methylbenzofuran-2-carbonitrile

Procedure

The title compound was prepared as described in general reductive amination procedure, starting from 3-bromo-4-(trifluoromethoxy)aniline and 6-formyl-3-methylbenzofuran-2-carbonitrile, Intermediate 4. LCMS retention time=1.64 minutes (LC method 3); MS (m+1)=426.0.

Sources & evidence

ORD record
ord-14853d0588204c10a9c49f852772dea8
Source dataset
uspto-grants-2016_02
Patent number
US09255093B2

Reaction notes

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