Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1773233Generated: October 26, 2026

3-Bromo-4-(trifluoromethoxy)aniline → 6-(((3-Bromo-4-(trifluoromethoxy)phenyl)amino)methyl)-3-methylbenzofuran-2-carbonitrile

https://huagongshe.com/reaction/1773233

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromo-4-(trifluoromethoxy)anilineHCID 2736418—
Reactant6-Formyl-3-methylbenzofuran-2-carbonitrileHCID 118452659—
Product6-(((3-Bromo-4-(trifluoromethoxy)phenyl)amino)methyl)-3-methylbenzofuran-2-carbonitrileHCID 118452646—

Reaction Steps

The title compound was prepared as described in general reductive amination procedure, starting from 3-bromo-4-(trifluoromethoxy)aniline and 6-formyl-3-methylbenzofuran-2-carbonitrile, Intermediate 4. LCMS retention time=1.64 minutes (LC method 3); MS (m+1)=426.0.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09255093B2
Source datasetuspto-grants-2016_02
ORD IDord-14853d0588204c10a9c49f852772dea8
Source noteuspto-grants-2016_02