HCID 71617090, compound → HCID 71617091, compound

HRID 1773296Notes

Reaction equation

HRID 1773296 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23]1=[CH:27][C:28]([O:32][CH2:33][CH:34]3[CH2:39][O:38][CH2:37][CH2:36][O:35]3)=[N:29][C:30](=[O:31])[N:22]1[CH2:21][CH2:20]2)=O)(C)(C)C>C1COCC1.CN(C=O)C>[O:35]1[CH2:36][CH2:37][O:38][CH2:39][CH:34]1[CH2:33][O:32][C:28]1[CH:27]=[C:23]2[C:24]3[C:19]([CH2:20][CH2:21][N:22]2[C:30](=[O:31])[N:29]=1)=[CH:18][C:17]([C:9]1[NH:8][C:16]2[C:11]([CH:10]=1)=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:26][CH:25]=3

Participants

3

Reactant 1

HCID 71617090HCID 71617090, compound

Product 1

HCID 71617091HCID 71617091, compound

Reagents, catalysts & solvents 1

HCID 21974620tetrahydrofuran N,N-dimethylformamideSolvent

Procedure

Compound 12 (57 mg, 0.11 mmol) was dissolved in a mixture of DCM/TFA (1/1, 2 mL) and the reaction was stirred at RT for 6 h. The mixture was evaporated to dryness to recover compound 13 as a TFA salt.

Workup

  1. customThe mixture was evaporated to dryness
  2. customto recover compound 13 as a TFA salt

Sources & evidence

ORD record
ord-e06db254140c4bd4831239bade9e84f0
Source dataset
uspto-grants-2016_02
Patent number
US09255095B2

Reaction notes

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