反应详情

The product (1.59 g, 3.3 mmol) obtained from Step 2, potassium carbonate (1.82 g, 13.2 mmol) and 20 ml methanol were mixed in a reactor, and stirred at room temperature under the protection of an inert gas atmosphere for 3 hours. After completion of the reaction, methanol was removed on a rotary evaporator and the mixture was extracted with ethyl acetate and water. The organic layers were combined, washed with a saturated NaCl solution, and dried over anhydrous Na2SO4. The organic solution was concentrated on a rotary evaporator, and the residue was purified by silica gel column chromatography, to give a yellow oily liquid.

1. customwas removed on a rotary evaporator
2. extractionthe mixture was extracted with ethyl acetate and water
3. washwashed with a saturated NaCl solution
4. dry with materialdried over anhydrous Na2SO4
5. concentrationThe organic solution was concentrated on a rotary evaporator
6. customthe residue was purified by silica gel column chromatography
7. customto give a yellow oily liquid