5-bromo-2-(1H-imidazol-2-yl)pyridine → 4-methyl-3-((2-(1H-imidazol-2-yl)pyridin-5-yl)ethynyl)-N-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]benzamide

HRID 1773475Notes

Reaction equation

HRID 1773475 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]2[NH:9][CH:10]=[CH:11][N:12]=2)=[N:6][CH:7]=1.[C:13]([C:15]1[CH:16]=[C:17]([CH:39]=[CH:40][C:41]=1[CH3:42])[C:18]([NH:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][N:28]2[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]2)=[C:23]([C:35]([F:38])([F:37])[F:36])[CH:22]=1)=[O:19])#[CH:14]>>[CH3:42][C:41]1[CH:40]=[CH:39][C:17]([C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([CH2:27][N:28]3[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]3)=[C:23]([C:35]([F:36])([F:38])[F:37])[CH:22]=2)=[O:19])=[CH:16][C:15]=1[C:13]#[C:14][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[NH:9][CH:10]=[CH:11][N:12]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 234385475-bromo-2-(1H-imidazol-2-yl)pyridineHCID 577373983-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Product 1

HCID 760728334-methyl-3-((2-(1H-imidazol-2-yl)pyridin-5-yl)ethynyl)-N-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]benzamide

Procedure

The title compound was prepared using 5-bromo-2-(1H-imidazol-2-yl)pyridine and 3-ethynyl-4-methyl-N-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]benzamide as raw materials, according to the method described in Step 4 of Example 3.

Sources & evidence

ORD record
ord-9398eaaa959d4a13a908d676b0cbcee8
Source dataset
uspto-grants-2016_02
Patent number
US09255107B2

Reaction notes

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