HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-bromo-2-(1H-imidazol-2-yl)pyridine → 4-methyl-3-((2-(1H-imidazol-2-yl)pyridin-5-yl)ethynyl)-N-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-bromo-2-(1H-imidazol-2-yl)pyridine | HCID 23438547 | — |
| Reactant | 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide | HCID 57737398 | — |
| Product | 4-methyl-3-((2-(1H-imidazol-2-yl)pyridin-5-yl)ethynyl)-N-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]benzamide | HCID 76072833 | — |
Reaction Steps
The title compound was prepared using 5-bromo-2-(1H-imidazol-2-yl)pyridine and 3-ethynyl-4-methyl-N-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]benzamide as raw materials, according to the method described in Step 4 of Example 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09255107B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-9398eaaa959d4a13a908d676b0cbcee8 |
| Source note | uspto-grants-2016_02 |