Trimethylsilylacetylene → HCID 76072865, compound

HRID 1773476Notes

Reaction equation

HRID 1773476 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[CH2:10][N:11]1[CH2:15][CH2:14][C@H:13]([N:16]([CH3:18])[CH3:17])[CH2:12]1)[NH2:6].I[C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][C:30]=1[CH3:31])[C:25](Cl)=[O:26].C[Si]([C:36]#[CH:37])(C)C.Br[C:39]1[CH:40]=[CH:41][C:42]([C:45]2[NH:46][C:47]([F:50])=[CH:48][N:49]=2)=[N:43][CH:44]=1>>[CH3:31][C:30]1[CH:29]=[CH:28][C:24]([C:25]([NH:6][C:5]2[CH:7]=[CH:8][C:9]([CH2:10][N:11]3[CH2:15][CH2:14][C@H:13]([N:16]([CH3:17])[CH3:18])[CH2:12]3)=[C:3]([C:2]([F:1])([F:19])[F:20])[CH:4]=2)=[O:26])=[CH:23][C:22]=1[C:36]#[C:37][C:39]1[CH:40]=[CH:41][C:42]([C:45]2[NH:46][C:47]([F:50])=[CH:48][N:49]=2)=[N:43][CH:44]=1

Participants

5

Reactant 4

HCID 66111TrimethylsilylacetyleneHCID 177521573-Iodo-4-methylbenzoyl chlorideHCID 71512240HCID 71512240, compoundHCID 118412713HCID 118412713, compound

Product 1

HCID 76072865HCID 76072865, compound

Procedure

The title compound was prepared using (S)-3-trifluoromethyl-4-(3-dimethylaminotetrahydropyrrol-1-yl)methylaniline, 3-iodo-4-methylbenzoyl chloride, trimethylsilylacetylene and 5-bromo-2-(5-fluoro-1H-imidazol-2-yl)pyridine as raw materials, according to the method described in Example 3.

Sources & evidence

ORD record
ord-6a7ad29e110241ad86f1191bf6956523
Source dataset
uspto-grants-2016_02
Patent number
US09255107B2

Reaction notes

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