HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilylacetylene → 3-trifluoromethyl-5-(4-methylimidazol-1-yl)-N-[3-(2-(5-trifluoromethyl-1H-imidazol-2-yl)pyridin-5-yl)ethynyl-4-fluorophenyl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 4-Fluoro-3-iodoaniline | HCID 19856330 | — |
| Reactant | 3-Trifluoromethyl-5-(4-methylimidazol-1-yl)benzoyl chloride | HCID 118412530 | — |
| Reactant | 2-(5-Trifluoromethylimidazol-2-yl)-5-bromopyridine | HCID 118412740 | — |
| Product | 3-trifluoromethyl-5-(4-methylimidazol-1-yl)-N-[3-(2-(5-trifluoromethyl-1H-imidazol-2-yl)pyridin-5-yl)ethynyl-4-fluorophenyl]-benzamide | HCID 90202167 | — |
Reaction Steps
The title compound was prepared using 3-trifluoromethyl-5-(4-methylimidazol-1-yl)benzoyl chloride, 3-iodo-4-fluoroaniline, trimethylsilylacetylene and 2-(5-trifluoromethylimidazol-2-yl)-5-bromopyridine as raw materials, according to the method described in Example 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09255107B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-edaada5842dd4b0aa10313707b9c3f19 |
| Source note | uspto-grants-2016_02 |