HRID1773477

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66111

Trimethylsilylacetylene

C5H10Si

HCID19856330

4-Fluoro-3-iodoaniline

C6H5FIN

结构：Cc1cn(-c2cc(C(=O)Cl)cc(C(F)(F)F)c2)cn1

HCID118412530

未命名化合物

HCID118412740

未命名化合物

PRODUCTS

生成物

结构：Cc1cn(-c2cc(C(=O)Nc3ccc(F)c(C#Cc4ccc(-c5ncc(C(F)(F)F)[nH]5)nc4)c3)cc(C(F)(F)F)c2)cn1

HCID90202167

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using 3-trifluoromethyl-5-(4-methylimidazol-1-yl)benzoyl chloride, 3-iodo-4-fluoroaniline, trimethylsilylacetylene and 2-(5-trifluoromethylimidazol-2-yl)-5-bromopyridine as raw materials, according to the method described in Example 3.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-edaada5842dd4b0aa10313707b9c3f19
来源数据集: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09255107B2
来源说明: uspto-grants-2016_02

反应 SMILES

[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([N:12]2[CH:16]=[C:15]([CH3:17])[N:14]=[CH:13]2)[CH:11]=1)[C:6](Cl)=[O:7].I[C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=1[F:28])[NH2:24].C[Si]([C:33]#[CH:34])(C)C.[F:35][C:36]([F:50])([F:49])[C:37]1[NH:41][C:40]([C:42]2[CH:47]=[CH:46][C:45](Br)=[CH:44][N:43]=2)=[N:39][CH:38]=1>>[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([N:12]2[CH:16]=[C:15]([CH3:17])[N:14]=[CH:13]2)[CH:11]=1)[C:6]([NH:24][C:23]1[CH:25]=[CH:26][C:27]([F:28])=[C:21]([C:33]#[C:34][C:45]2[CH:46]=[CH:47][C:42]([C:40]3[NH:41][C:37]([C:36]([F:50])([F:49])[F:35])=[CH:38][N:39]=3)=[N:43][CH:44]=2)[CH:22]=1)=[O:7]