反应详情

A mixture of N-(4-ethyl-3-nitro-phenyl)-acetamide (1.0 g) and concentrated hydrochloric acid (5 mL) was heated at reflux for 4 hours. The reaction mixture was then cooled, basified by addition of sodium hydroxide and extracted twice with diethyl ether. The combined organic extracts were dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to afford 0.601 g of 4-ethyl-3-nitro-phenylamine without further purifications. MS=167 [M+H]+.

1. temperaturewas heated
2. temperatureat reflux for 4 hours
3. temperatureThe reaction mixture was then cooled
4. extractionextracted twice with diethyl ether
5. dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
6. filtrationfiltered
7. customevaporated under reduced pressure