2-Bromopropanedial → 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid
Reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[CH:4][C:3]=1[C:7]([OH:9])=[O:8].[Br:10][CH:11]([CH:14]=O)[CH:12]=O>Cl>[Br:10][C:11]1[CH:12]=[N:1][C:2]2[N:6]([N:5]=[CH:4][C:3]=2[C:7]([OH:9])=[O:8])[CH:14]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 95 °C
Procedure
A suspension of 5-amino-1H-pyrazole-4-carboxylic acid (1 g, 7.8 mmol) and 2-bromomalonaldehyde (1.2 g, 7.8 mmol) in an aqueous solution of hydrochloric acid (6 M, 20 mL) was heated at 95° C. for 15 minutes. The resulting mixture was cooled to room temperature and the solid formed was collected by filtration, rinsed with water and dried in vacuum oven to give 6-bromo-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid.
Workup
- temperatureThe resulting mixture was cooled to room temperature
- customthe solid formed
- filtrationwas collected by filtration
- washrinsed with water
- customdried in vacuum oven
Sources & evidence
- ORD record
- ord-9b3823f6912d4d0e9283a25f56c57522
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09255110B2
Reaction notes
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