Hydrogen Bromide → HCID 46835270, compound

HRID 1773637Notes

Reaction equation

HRID 1773637 reaction equation
[Br:1][C:2]1[C:3]2[N:4]([C:9](I)=[CH:10][N:11]=2)[N:5]=[C:6](Cl)[CH:7]=1.[BrH:13].O>C(O)(=O)C>[Br:13][C:6]1[CH:7]=[C:2]([Br:1])[C:3]2[N:4]([CH:9]=[CH:10][N:11]=2)[N:5]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 86662987HCID 86662987, compound

Product 1

HCID 46835270HCID 46835270, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 5.0 (14.0 mmol) 8-bromo-6-chloro-3-iodoimidazo[1,2-b]pyridazine which was prepared according to intermediate example 1c, 30 mL of hydrogen bromide solution in acetic acid (33%) was stirred at 120° C. for 1 hour under microwave irradiation. The mixture was poured into water and extracted with dichloromethane. The organic phase was washed with sodium thiosulfate and sodium hydrogencarbonate solution and dried over sodium sulfate. After filtration and removal of solvent the residue was purified by chromatography to give 3.0 g (78%) of the title compound.

Workup

  1. customwas prepared
  2. extractionextracted with dichloromethane
  3. washThe organic phase was washed with sodium thiosulfate and sodium hydrogencarbonate solution
  4. dry with materialdried over sodium sulfate
  5. filtrationAfter filtration and removal of solvent the residue
  6. customwas purified by chromatography

Sources & evidence

ORD record
ord-3aa9bcea2112441a967a719c9c3d08c7
Source dataset
uspto-grants-2016_02
Patent number
US09255100B2

Reaction notes

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