Water → HCID 66695610, compound

HRID 1773642Notes

Reaction equation

HRID 1773642 reaction equation
[CH:1]1([NH:4][C:5](=[O:28])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]4[N:17]=[C:18]([S:26][CH3:27])[CH:19]=[C:20]([NH:21][CH2:22][CH:23]([CH3:25])[CH3:24])[C:15]4=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.[OH:29]OS([O-])=O.[K+].[OH2:35]>CN(C=O)C>[CH:1]1([NH:4][C:5](=[O:28])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]4[N:17]=[C:18]([S:26]([CH3:27])(=[O:29])=[O:35])[CH:19]=[C:20]([NH:21][CH2:22][CH:23]([CH3:25])[CH3:24])[C:15]4=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 66693427HCID 66693427, compound

Product 1

HCID 66695610HCID 66695610, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 410 mg (1037 μmol) of N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(methylsulfanyl)imidazo[1,2-b]pyridazin-3-yl}benzamide, which was prepared according to example 193, in 15 mL of DMF was added and 1912 mg (3110 μmol) OXONE (potassium peroxymonosulfate) in small portions. The mixture was stirred over night, then cooled to 0° C. and poured onto 200 mL of cold water. The precipitate was collected and dried under vacuum to yield 291 mg of the title compound as a yellow solid.

Workup

  1. additionwas added
  2. customThe precipitate was collected
  3. customdried under vacuum

Sources & evidence

ORD record
ord-ac2c71edcc69470b93ac58d4ccd2da8a
Source dataset
uspto-grants-2016_02
Patent number
US09255100B2

Reaction notes

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