Dichloromethane → 4-bromo-2-hydroxy-N-[2-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]quinazolin-5-yl]oxypropyl]butanamide
Reaction equation
[C:58]([Br:59])([Br:60])([Br:61])[Br:62].[Cl:63][CH2:64][Cl:65].[OH:20][CH:21]([C:22](=[O:23])[NH:24][CH2:25][CH:26]([CH3:27])[O:28][c:29]1[c:30]2[c:31]([NH:39][c:40]3[cH:41][c:42]([CH3:54])[c:43]([O:46][c:47]4[cH:48][n:49][c:50]([CH3:53])[cH:51][cH:52]4)[cH:44][cH:45]3)[n:32][cH:33][n:34][c:35]2[cH:36][cH:37][cH:38]1)[CH2:55][CH2:56][OH:57].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[OH:20][CH:21]([C:22](=[O:23])[NH:24][CH2:25][CH:26]([CH3:27])[O:28][c:29]1[c:30]2[c:31]([NH:39][c:40]3[cH:41][c:42]([CH3:54])[c:43]([O:46][c:47]4[cH:48][n:49][c:50]([CH3:53])[cH:51][cH:52]4)[cH:44][cH:45]3)[n:32][cH:33][n:34][c:35]2[cH:36][cH:37][cH:38]1)[CH2:55][CH2:56][Br:59]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-367d2ab07d6c4358935cfdfd6e1239db
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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