Bromine → HCID 87110339, compound

HRID 1773650Notes

Reaction equation

HRID 1773650 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([Br:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[Br:12]Br>C(O)(=O)C>[Br:12][C:8]1[N:6]2[N:7]=[C:2]([Br:1])[CH:3]=[C:4]([Br:11])[C:5]2=[N:10][CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 46835270HCID 46835270, compound

Product 1

HCID 87110339HCID 87110339, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a stirred suspension of 100.00 g (361.1 mmol) 6,8-dibromoimidazo[1,2-b]pyridazine, which was prepared according to intermediate example 96d, in 1.6 L acetic acid were added 69.2 g (433.3 mmol) bromine at it and the mixture was stirred for 1 h. The precipitate was filtered, washed with water and dissolved in 10 L DCM. The organic üphase was washed with saturated sodium hydrogen carbonate solution, dried over sodium sulfate, filtered and evaporated to give 81.99 g (64%) of the title compound.

Workup

  1. customwas prepared
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. dissolutiondissolved in 10 L DCM
  5. washThe organic üphase was washed with saturated sodium hydrogen carbonate solution
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated

Sources & evidence

ORD record
ord-4a93771476534ec9aab1f3f86c2fd8a1
Source dataset
uspto-grants-2016_02
Patent number
US09255100B2

Reaction notes

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