Bromine → HCID 87110339, compound

Participants

Reaction Steps

To a stirred suspension of 100.00 g (361.1 mmol) 6,8-dibromoimidazo[1,2-b]pyridazine, which was prepared according to intermediate example 96d, in 1.6 L acetic acid were added 69.2 g (433.3 mmol) bromine at it and the mixture was stirred for 1 h. The precipitate was filtered, washed with water and dissolved in 10 L DCM. The organic üphase was washed with saturated sodium hydrogen carbonate solution, dried over sodium sulfate, filtered and evaporated to give 81.99 g (64%) of the title compound.

Provenance & Evidence