Diisopropylethylamine → HCID 66691610, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 96 mg (200 μmol) N-cyclopropyl-4-[6-(3-fluorophenoxy)-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide which was prepared according to intermediate example 486a in 2 mL NMP is added 77.5 mg (0.6 mmol) 3-amino-1,1,1-trifluoropropan-2-ol and 77.5 mg (0.6 mmol) DIPEA and the mixture is heated at 160° C. for 30 min in a microwave oven. After working up and purification 10.5 mg (9%) of the title compound are obtained.

Provenance & Evidence