Diisopropylethylamine → HCID 66691610, compound

HRID 1773652Notes

Reaction equation

HRID 1773652 reaction equation
[CH:1]1([NH:4][C:5](=[O:34])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]4[N:17]=[C:18]([O:25][C:26]5[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=5)[CH:19]=[C:20](S(C)(=O)=O)[C:15]4=[N:14][CH:13]=3)=[CH:8][C:7]=2[CH3:33])[CH2:3][CH2:2]1.[NH2:35][CH2:36][CH:37]([OH:42])[C:38]([F:41])([F:40])[F:39].CCN(C(C)C)C(C)C>CN1C(=O)CCC1>[CH:1]1([NH:4][C:5](=[O:34])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]4[N:17]=[C:18]([O:25][C:26]5[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=5)[CH:19]=[C:20]([NH:35][CH2:36][CH:37]([OH:42])[C:38]([F:41])([F:40])[F:39])[C:15]4=[N:14][CH:13]=3)=[CH:8][C:7]=2[CH3:33])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 4189653-Amino-1,1,1-trifluoropropan-2-olHCID 66695753HCID 66695753, compound

Product 1

HCID 66691610HCID 66691610, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
160 °C

Procedure

To a stirred solution of 96 mg (200 μmol) N-cyclopropyl-4-[6-(3-fluorophenoxy)-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide which was prepared according to intermediate example 486a in 2 mL NMP is added 77.5 mg (0.6 mmol) 3-amino-1,1,1-trifluoropropan-2-ol and 77.5 mg (0.6 mmol) DIPEA and the mixture is heated at 160° C. for 30 min in a microwave oven. After working up and purification 10.5 mg (9%) of the title compound are obtained.

Workup

  1. custompurification 10.5 mg (9%) of the title compound
  2. customare obtained

Sources & evidence

ORD record
ord-d5ce85f83a594440a162c5706ea0e3d5
Source dataset
uspto-grants-2016_02
Patent number
US09255100B2

Reaction notes

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