Tramiprosate → HCID 86705362, compound

Participants

Reaction Steps

To a stirred solution of 41 mg (300 μmol) 3-aminopropane-1-sulfonic acid in 2 mL DMSO is added 24 mg (600 μmol) sodium hydride at rt. After 30 min, 90 mg (200 μmol) 4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methyl benzamide are added which was prepared according to intermediate example 516b to give after stirring for 2 h, the crude title compound which was used after evaporation of the solvent without further workup.

Provenance & Evidence